Clinical Research

The McGuire Institute

2021 - Present

Asua 001-2020: Development of an Artificial Intelligence Platform/Digital Dental Hygienist to Improve Compliance in Periodontal Maintenance Patients

Sponsor: Asua, Inc

Principal Investigator: Michael K. McGuire, DDS

Co-Investigator: E. Todd Scheyer, DDS, MS and Andrew Rossi, DDS, MSD

The McGuire Institute

2020 - Present

A Pilot Study for Healing and Safety Outcomes in Creating Site Appropriate Keratinized Tissue Comparing Markman Biologics Microsurfaced ADM and AlloDerm ADM

Sponsor: Markman Biologics, LLC

Principal Investigator: Michael K. McGuire, DDS

Co-Investigator: E. Todd Scheyer, DDS, MS

Geistlich Pharma AG

2019 - Present

A Prospective, Randomized and Controlled Multi-Center Study to Assess Safety and Non-Inferiority Effectiveness of Geistlich Fibro-Gide® Compared with connective Tissue Graft for Soft Tissue Volume Augmentation Around Dental Implants.”

Sponsor: Geistlich Pharma AG

Principal Investigator: Michael K. McGuire, DDS and E. Todd Scheyer, DDS, MS

The McGuire Institute

2020 - 2021

A Retrospective Analysis of Dental Healthcare Provider (DHCP) Safety in the Dental Setting During the COVID-19 Pandemic: A McGuire Institute Report

Sponsor: The McGuire Institute

Principal Investigator: Michael K. McGuire, DDS, E. Todd Scheyer, DDS, MS and Andrew Rossi, DDS, MSD

Geistlich Pharma AG

2019 - 2021

A Case Series Trial to Evaluate the Safety, Tolerability and Efficacy of Clarix Flo for the Treatment of Periodontitis Furcation Defects

Sponsor: Geistlich Pharma AG

Principal Investigator: Michael K. McGuire, DDS and E. Todd Scheyer, DDS, MS

Geistlich Pharma AG

2019 - 2020

A Phase 2 Trial to Evaluate the Safety, Tolerability and Efficacy of PerioSept® (3%) as adjunct to Scaling and Root Planing in Subjects with Periodontitis

Sponsor: Geistlich Pharma AG

Principal Investigator: Michael K. McGuire, DDS

Co-Investigator: E. Todd Scheyer, DDS, MS

Geistlich Pharma AG

Recession Study 2018-Present

A prospective, randomized, controlled, double-blind, multi-center study to assess non-inferiority of Geitslich Fibro-Gide® in comparison to connective tissue graft for the treatment of recession defects.

Sponsor: Geistlich Pharma AG

Principal Investigator: Michael K. McGuire, DDS

Waterlase by Biolase

2017 - 2020

A prospective Multicenter Randomized and Controlled Study Comparing Laser and Mist Therapies for Treatment of Moderate to Severe Generalized Periodontitis

Sponsor: Waterlase by Biolase

Principal Investigator: Michael K. McGuire, DDS

Co-Investigator: E. Todd Scheyer, DDS, MS

Geistlich Pharma AG

2016 – 2018

A pharmacokinetic Pilot followed by a Phase I/II, Blinded, Randomized, Controlled, Parallel Arm Trial to Evaluate the Safety, Tolerability and Efficacy of PerioSept® and Scaling and Root Planing in Subjects with Periodontitis.

Sponsor: Geistlich Pharma AG

Principal Investigator: Michael K. McGuire, DDS

Co-Investigator: E. Todd Scheyer, DDS, MS

Geistlich Pharma AG

2016 - 2017

A prospective, randomized, controlled, multi-center evaluation of extraction socket management comparing CollaPlug® and Mucograft Seal®

Sponsor: Geistlich Pharma NA

Principal Investigator: Michael K. McGuire, DDS and E. Todd Scheyer, DDS, MS

The McGuire Institute

2016

Long-term Clinical Evaluation of Dental Implants.

Sponsor: The McGuire Institute

Principal Investigator: Michael K. McGuire, DDS and E. Todd Scheyer, DDS, MS

Geistlich Pharma AG

2015 - 2016

A pharmacokinetic Pilot followed by a Phase I/II, Blinded, Randomized, Controlled, Parallel Arm Trial to Evaluate the Safety, Tolerability and Efficacy of PerioSept® and Scaling and Root Planing in Subjects with Periodontitis.

Sponsor: Giestlich

Principal Investigator: Michael K. McGuire, DDS

Co-Investigator: E. Todd Scheyer, DDS, MS

Luitpold

2012 - 2014

Evaluation of Human Ginigival Recesion Defects Treated with Coronally Advanced Flaps and Either β-TCP + rhPDGF-BB (GEM 21S®) or Connective Tissue: Comparison of Clinical Parameters at 5 or More Years Floowing Completion of Protocol 1GEM04001

Sponsor: Luitpold

Principal Investigator: Michael K. McGuire, DDS

Co-Investigator: E. Todd Scheyer, DDS, MS

Keystone Dental

2011 - 2017

Clinical Analysis of a Biomimetric Implant System: Five Year survival rates, Marginal Bone-Level Changes, and Soft tissue Aesthetics

Sponsor: Keystone Dental

Principal Investigator: E. Todd Scheyer, DDS, MS

Co-Investigator: Michael k. McGuire, DDS

Straumann

2011 - 2016

A Prospective, Case-Controlled Study Evaluating the Use of Straumann Emdogain with Coronally Advanced Flap Versus Connective Tissue Graft with Coronally Advanced Flap on Human Buccal Recession Defects; A Human Histology Study

Sponsor: Straumann

Principal Investigator: Michael K. McGuire, DDS

Co-Investigator: E.Todd Scheyer, DDS, MS

Geistlich Pharma AG

2010 - 2013

A Clinical Trial to Evaluate Mucograft® Collagen Matrix as an Alternative to Free Gingival Grafting for Oral Soft Tissue Augmentation

Sponsor: Geistlich Pharma AG

Principal Investigator: Michael K. McGuire, DDS

Co-Investigator: E.Todd Scheyer, DDS, MS

Astra Tech Implant System

2008 - 2014

Prospective Comparative Assessment of Single-Tooth Replacement in Different Implant-Abutment Interface Settings

Sponsor: Astra Tech Implant System

Principal Investigator: Michael K. McGuire, DDS

Co-Investigator: E. Todd Scheyer, DDS, MS

Medtronic

2009 - 2011

An Open label, Non-Randomized, Single-Arm, Multi-Center Study to Assess Sinus Augmentation (Sinus Lift) Utilizing INFUSE® Bone Graft Concurrent with Dental Implant Placement

Sponsor: Medtronic

Principal Investigator: Michael K. McGuire, DDS and E.Todd Scheyer, DDS, MS

Keystone Dental

2009 - 2010

A Post-Market Clinical, Radiographic and Histologic Evaluation of DynBlast ™ DBM Putty and Paste in Extraction Socket Procedures

Sponsor: Keystone

Principal Investigator: E. Todd Scheyer, DDS, MS

Co-Investigator: Michael K. McGuire, DDS

Organogenesis

2007 - 2010

A Prospective, Randomized, Controlled Pilot Study of CelTx™ (Apligraf®)* as an Alternative to Tissue from the Palate in the Treatment of Gingival Recession Requiring Root Coverage

Sponsor: Organogenesis

Principal Investigator: Michael K. McGuire, DDS

Co-Investigator: E. Todd Scheyer, DDS, MS

Luitpold

2009

Clinical Evaluation of GEM 21S® Containing a narrower Particle Range of β-Tricalcium Phosphate in Human Periodontal osseous Defects

Sponsor: Luitpold

Principal Investigator: Michael K. McGuire, DDS and E.Todd Scheyer, DDS, MS

Organogenesis

2007 - 2009

A Clinical Trial to Evaluate CelTx™ (Apligraf®) as an Alternative to Tissue From the Palate to Enhance Oral Soft Tissue Regeneration and Wound Healing

Sponsor: Organogenesis

Principal Investigator: Michael K. McGuire, DDS

Co-Investigator: E. Todd Scheyer, DDS, MS

Organogenesis

2007 - 2008

A Clinical Trial to Evaluate CelTx™ (Apligraf®) as an Alternative to Tissue From the Palate to Enhance Oral Soft Tissue Regeneration and Wound Healing

Sponsor: Organogenesis

Principal Investigator: Michael K. McGuire, DDS

Co-Investigator: E. Todd Scheyer, DDS, MS

Perio Health Professionals

2007 - 2009

A Prospective randomized Controlled Study of Bio-Guide, Ossix™, and Ossix Plus™ Membranes used in Guided Bone Regeneration of Dehiscence and Fenestration Cases

Sponsor: Perio Health Clinical Research Center

Principal Investigator: Michael K. McGuire, DDS

Co-Investigator: E. Todd Scheyer, DDS, MS

Geistlich Pharma AG

2006 - 2008

A Single- Blind, Controlled, Split-Mouth, Single-Center Clinical Trial to Evaluate the Safety and Effectiveness of Mucograft™ compared to Subepithelial Connective Tissue Graft (CTG) for the Treatment of Dehiscence-Type Recession Periodontal Defects

Sponsor: Geistlich Pharma G

Principal Investigator: Michael K. McGuire, DDS

Co-Investigator: E. Todd Scheyer, DDS, MS

Isolagen

2005 - 2008

A Phase II Open-Label Study to Determine the Saftey and Efficacy of Isolagen™ Therapy for Treatment of Interdental Papillary Insufficiency.

Sponsor: Isolagen

Principal Investigator: Michael K. McGuire, DDS

Co-Investigator: E.Todd Scheyer, DDS, MS

Luitpold

2005 - 2007

A Single-Blind, Controlled, Split Mouth, Single- Center Study to Evaluate Saftey and Effectiveness of GEM 21S Associated with GTR Membrane Compared to Sub-epithelial Connective Tissue Graft (CTG) for Treatment of Recession-Type Periodontal Defects

Sponsor: Osteohealth/Luitpold

Principal Investigator: Michael K. McGuire, DDS

Co-Investigator: E. Todd Scheyer, DDS, MS

3i Implant Innovations

2004 - 2006

A Prospective, Randomized-Controlled Study of Ossixä and Bio-Guideâ Membranes used in Guided Bone Regeneration of Dehiscence and Fenestration Cases.

Sponsor: 3i Implant Innovations

Principal Investigator: Michael K. McGuire, DDS

Co-Investigator: E. Todd Scheyer, DDS, MS

Organogenesis

2005 - 2006

A Pilot Clinical Trial to Assess the Safety and Efficacy of Apligraf® in Establishing a Functional Zone of Attached Gingiva

Sponsor: Organogenesis

Principal Investigator: Michael K. McGuire DDS

Co-Investigator: E.Todd Scheyer, DDS, MS

Isolagen

2004 - 2006

A Phase II, Randomized, Double-Blind, Placebo-Controlled Study to Determine the Safety and Efficacy of Isolagen Injections for Treatment of Interdentally Papillary Insufficiency

Sponsor: Isolagen

Principal Investigator: Michael K. McGuire, DDS

Co-Investigator: E.Todd Scheyer, DDS, MS

Perio Health Professionals

2003 - 2004

A Blinded-Human clinical Trial to Evaluate the Clinical Utility of GEM 21S for the Treatment of General Bone Defects

Sponsor: Biomimetic Pharmaceuticals

Principal Investigator: Michael K. McGuire, DDS

Co-Investigator: E.Todd Scheyer, DDS, MS

Perio Health Professionals

2002 - 2003

A Randomized Double-Blind, Controlled, Parallel-Arm, Pivotal Human Clinical Trial to Evaluate the Safety and Effectiveness of B-TCP Plus for the Treatment of Periodontal Bone Defects

Sponsor: Biomimetic Pharmaceuticals

Principal Investigator: Michael K. McGuire, DDS

Co-Investigator: E.Todd Scheyer, DDS, MS

Advanced Tissue Sciences

2000 - 2002

Free Autogenous Graft Pilot Study Utilizing Human Dermal Fibroblasts

Sponsor: Advanced Tissue Sciences

Principal Investigator: Michael K. McGuire, DDS

OraPharma

2000 - 2001

A Pilot Study of the Clinical applicability of the Minocycline Periodontal Therapeutics System When Used Adjunctively with Scaling and Root Planing for the Treatment of Non-Responding Periodontal Sites

Sponsor: OraPharma

Principal Investigator: Michael K. McGuire, DDS

Perio Health Professionals

1999 - 2001

The Evaluation of Emdogain ® in Treatment of Recession Type Defects

Sponsor: Biora

Principal Investigator: Michael K. McGuire, DDS

Proctor & Gamble

1994 - 1995

Host Factor Relationships in Periodontal Regenerative Therapy

Sponsor: Proctor & Gamble

Principal Investigator: Michael K. McGuire, DDS

Proctor & Gamble

1994

A Six Month Multicenter Evaluation of Adjunctive Tetracycline Fiber therapy used in Conjunction with Scaling and Root Planing in Maintenance Patients

Sponsor: Proctor & Gamble

Principal Investigator: Michael K. McGuire, DDS

Proctor & Gamble

1993 - 1994

Adjunctive use of Azithromycin in Treatment of Refractory Periodontitis

Sponsor: Proctor & Gamble

Principal Investigator: Michael K. McGuire, DDS

The McGuire Institute

1990

Clinical and Microbial Patterns of Adults with Periodontitis

Sponsor: Michael K. McGuire, DDS

Principal Investigator: Michael K. McGuire, DDS

Proctor & Gamble

1989 - 1994

Open-Label Study to Evaluate Treatment Use of PTS (Periodontal Therapeutic System) (Tetracycline)

Sponsor: Proctor Gamble/Alza Corp

Principal Investigator: Michael K. McGuire, DDS

Perio Health Professionals

1989 - 1990

A Multi-Center Study to Evaluate Scaling & Root Planing With and Without PTS (Periodontal Therapeutic System) (Tetracycline) in Refractory Maintenance Patients

Sponsor: Alza Corp

Principal Investigator: Michael K. McGuire, DDS