Clinical Research
The research department at Perio Health Professionals has been fortunate to be involved in a variety of diverse research projects since 1989. What started with an occasional collaboration between Dr. McGuire and several other nationally respected periodontists, who were also innovative leaders in their field, led to the formation of an organized research institute. The McGuire Institute was founded by Dr. McGuire and Dr. Scheyer in 2010. Under the guidance of Dr. McGuire and Dr. Scheyer, the institute has grown to involve 17 practice sites throughout the United States. They have now overseen and participated in 53 projects, providing high-quality research, which has resulted in several landmark clinical trials. As one of the seventeen sites, the research department at Perio Health Professionals has participated in all these trials.
Over the years, our research department at Perio Health Professionals has grown. Dr. Andrew Rossi, who has added expertise and enthusiasm to our team, joined Dr. McGuire and Dr. Scheyer in 2019. The department now includes our three doctors, two hygienists who serve as clinical coordinators, an international interning dentist, and data-management assistants. Our past trials have explored many focus areas, from biologic tissue engineering to implant placement to esthetic enhancement. Some of our more current trials have looked at a new type of implant, laser periodontal therapy, improved use of enhanced healing material for soft tissue grafts, as well as the effect of an artificial intelligence app on oral hygiene compliance and long-term oral health.
Along with the important aspect of gaining experience in cutting-edge technology and treatment modalities, we find it very rewarding to be able to provide treatment at no cost to our patients who qualify for studies. We enjoy collaborating with referring dentists to provide treatment their patients might not otherwise be able to afford.
We post upcoming studies on our website and look forward to continuing contribution to the improvement of dental treatments and education, making a difference in dentistry throughout the world through research.
Find out more information at www.TheMcGuireInstitute.org
2021 - Present
Asua 001-2020: Development of an Artificial Intelligence Platform/Digital Dental Hygienist to Improve Compliance in Periodontal Maintenance Patients
Sponsor: Asua, Inc
Principal Investigator: Michael K. McGuire, DDS
Co-Investigator: E. Todd Scheyer, DDS, MS and Andrew Rossi, DDS, MSD
2020 - Present
A Pilot Study for Healing and Safety Outcomes in Creating Site Appropriate Keratinized Tissue Comparing Markman Biologics Microsurfaced ADM and AlloDerm ADM
Sponsor: Markman Biologics, LLC
Principal Investigator: Michael K. McGuire, DDS
Co-Investigator: E. Todd Scheyer, DDS, MS
2019 - Present
A Prospective, Randomized and Controlled Multi-Center Study to Assess Safety and Non-Inferiority Effectiveness of Geistlich Fibro-Gide® Compared with connective Tissue Graft for Soft Tissue Volume Augmentation Around Dental Implants.”
Sponsor: Geistlich Pharma AG
Principal Investigator: Michael K. McGuire, DDS and E. Todd Scheyer, DDS, MS
2020 - 2021
A Retrospective Analysis of Dental Healthcare Provider (DHCP) Safety in the Dental Setting During the COVID-19 Pandemic: A McGuire Institute Report
Sponsor: The McGuire Institute
Principal Investigator: Michael K. McGuire, DDS, E. Todd Scheyer, DDS, MS and Andrew Rossi, DDS, MSD
2019 - 2021
A Case Series Trial to Evaluate the Safety, Tolerability and Efficacy of Clarix Flo for the Treatment of Periodontitis Furcation Defects
Sponsor: Geistlich Pharma AG
Principal Investigator: Michael K. McGuire, DDS and E. Todd Scheyer, DDS, MS
2019 - 2020
A Phase 2 Trial to Evaluate the Safety, Tolerability and Efficacy of PerioSept® (3%) as adjunct to Scaling and Root Planing in Subjects with Periodontitis
Sponsor: Geistlich Pharma AG
Principal Investigator: Michael K. McGuire, DDS
Co-Investigator: E. Todd Scheyer, DDS, MS
Recession Study 2018-Present
A prospective, randomized, controlled, double-blind, multi-center study to assess non-inferiority of Geitslich Fibro-Gide® in comparison to connective tissue graft for the treatment of recession defects.
Sponsor: Geistlich Pharma AG
Principal Investigator: Michael K. McGuire, DDS
2017 - 2020
A prospective Multicenter Randomized and Controlled Study Comparing Laser and Mist Therapies for Treatment of Moderate to Severe Generalized Periodontitis
Sponsor: Waterlase by Biolase
Principal Investigator: Michael K. McGuire, DDS
Co-Investigator: E. Todd Scheyer, DDS, MS
2016 – 2018
A pharmacokinetic Pilot followed by a Phase I/II, Blinded, Randomized, Controlled, Parallel Arm Trial to Evaluate the Safety, Tolerability and Efficacy of PerioSept® and Scaling and Root Planing in Subjects with Periodontitis.
Sponsor: Geistlich Pharma AG
Principal Investigator: Michael K. McGuire, DDS
Co-Investigator: E. Todd Scheyer, DDS, MS
2016 - 2017
A prospective, randomized, controlled, multi-center evaluation of extraction socket management comparing CollaPlug® and Mucograft Seal®
Sponsor: Geistlich Pharma NA
Principal Investigator: Michael K. McGuire, DDS and E. Todd Scheyer, DDS, MS
2016
Long-term Clinical Evaluation of Dental Implants.
Sponsor: The McGuire Institute
Principal Investigator: Michael K. McGuire, DDS and E. Todd Scheyer, DDS, MS
2015 - 2016
A pharmacokinetic Pilot followed by a Phase I/II, Blinded, Randomized, Controlled, Parallel Arm Trial to Evaluate the Safety, Tolerability and Efficacy of PerioSept® and Scaling and Root Planing in Subjects with Periodontitis.
Sponsor: Giestlich
Principal Investigator: Michael K. McGuire, DDS
Co-Investigator: E. Todd Scheyer, DDS, MS
2012 - 2014
Evaluation of Human Ginigival Recesion Defects Treated with Coronally Advanced Flaps and Either β-TCP + rhPDGF-BB (GEM 21S®) or Connective Tissue: Comparison of Clinical Parameters at 5 or More Years Floowing Completion of Protocol 1GEM04001
Sponsor: Luitpold
Principal Investigator: Michael K. McGuire, DDS
Co-Investigator: E. Todd Scheyer, DDS, MS
2011 - 2017
Clinical Analysis of a Biomimetric Implant System: Five Year survival rates, Marginal Bone-Level Changes, and Soft tissue Aesthetics
Sponsor: Keystone Dental
Principal Investigator: E. Todd Scheyer, DDS, MS
Co-Investigator: Michael k. McGuire, DDS
2011 - 2016
A Prospective, Case-Controlled Study Evaluating the Use of Straumann Emdogain with Coronally Advanced Flap Versus Connective Tissue Graft with Coronally Advanced Flap on Human Buccal Recession Defects; A Human Histology Study
Sponsor: Straumann
Principal Investigator: Michael K. McGuire, DDS
Co-Investigator: E.Todd Scheyer, DDS, MS
2010 - 2013
A Clinical Trial to Evaluate Mucograft® Collagen Matrix as an Alternative to Free Gingival Grafting for Oral Soft Tissue Augmentation
Sponsor: Geistlich Pharma AG
Principal Investigator: Michael K. McGuire, DDS
Co-Investigator: E.Todd Scheyer, DDS, MS
2008 - 2014
Prospective Comparative Assessment of Single-Tooth Replacement in Different Implant-Abutment Interface Settings
Sponsor: Astra Tech Implant System
Principal Investigator: Michael K. McGuire, DDS
Co-Investigator: E. Todd Scheyer, DDS, MS
2009 - 2011
An Open label, Non-Randomized, Single-Arm, Multi-Center Study to Assess Sinus Augmentation (Sinus Lift) Utilizing INFUSE® Bone Graft Concurrent with Dental Implant Placement
Sponsor: Medtronic
Principal Investigator: Michael K. McGuire, DDS and E.Todd Scheyer, DDS, MS
2009 - 2010
A Post-Market Clinical, Radiographic and Histologic Evaluation of DynBlast ™ DBM Putty and Paste in Extraction Socket Procedures
Sponsor: Keystone
Principal Investigator: E. Todd Scheyer, DDS, MS
Co-Investigator: Michael K. McGuire, DDS
2007 - 2010
A Prospective, Randomized, Controlled Pilot Study of CelTx™ (Apligraf®)* as an Alternative to Tissue from the Palate in the Treatment of Gingival Recession Requiring Root Coverage
Sponsor: Organogenesis
Principal Investigator: Michael K. McGuire, DDS
Co-Investigator: E. Todd Scheyer, DDS, MS
2009
Clinical Evaluation of GEM 21S® Containing a narrower Particle Range of β-Tricalcium Phosphate in Human Periodontal osseous Defects
Sponsor: Luitpold
Principal Investigator: Michael K. McGuire, DDS and E.Todd Scheyer, DDS, MS
2007 - 2009
A Clinical Trial to Evaluate CelTx™ (Apligraf®) as an Alternative to Tissue From the Palate to Enhance Oral Soft Tissue Regeneration and Wound Healing
Sponsor: Organogenesis
Principal Investigator: Michael K. McGuire, DDS
Co-Investigator: E. Todd Scheyer, DDS, MS
2007 - 2008
A Clinical Trial to Evaluate CelTx™ (Apligraf®) as an Alternative to Tissue From the Palate to Enhance Oral Soft Tissue Regeneration and Wound Healing
Sponsor: Organogenesis
Principal Investigator: Michael K. McGuire, DDS
Co-Investigator: E. Todd Scheyer, DDS, MS
2007 - 2009
A Prospective randomized Controlled Study of Bio-Guide, Ossix™, and Ossix Plus™ Membranes used in Guided Bone Regeneration of Dehiscence and Fenestration Cases
Sponsor: Perio Health Clinical Research Center
Principal Investigator: Michael K. McGuire, DDS
Co-Investigator: E. Todd Scheyer, DDS, MS
2006 - 2008
A Single- Blind, Controlled, Split-Mouth, Single-Center Clinical Trial to Evaluate the Safety and Effectiveness of Mucograft™ compared to Subepithelial Connective Tissue Graft (CTG) for the Treatment of Dehiscence-Type Recession Periodontal Defects
Sponsor: Geistlich Pharma G
Principal Investigator: Michael K. McGuire, DDS
Co-Investigator: E. Todd Scheyer, DDS, MS
2005 - 2008
A Phase II Open-Label Study to Determine the Saftey and Efficacy of Isolagen™ Therapy for Treatment of Interdental Papillary Insufficiency.
Sponsor: Isolagen
Principal Investigator: Michael K. McGuire, DDS
Co-Investigator: E.Todd Scheyer, DDS, MS
2005 - 2007
A Single-Blind, Controlled, Split Mouth, Single- Center Study to Evaluate Saftey and Effectiveness of GEM 21S Associated with GTR Membrane Compared to Sub-epithelial Connective Tissue Graft (CTG) for Treatment of Recession-Type Periodontal Defects
Sponsor: Osteohealth/Luitpold
Principal Investigator: Michael K. McGuire, DDS
Co-Investigator: E. Todd Scheyer, DDS, MS
2004 - 2006
A Prospective, Randomized-Controlled Study of Ossixä and Bio-Guideâ Membranes used in Guided Bone Regeneration of Dehiscence and Fenestration Cases.
Sponsor: 3i Implant Innovations
Principal Investigator: Michael K. McGuire, DDS
Co-Investigator: E. Todd Scheyer, DDS, MS
2005 - 2006
A Pilot Clinical Trial to Assess the Safety and Efficacy of Apligraf® in Establishing a Functional Zone of Attached Gingiva
Sponsor: Organogenesis
Principal Investigator: Michael K. McGuire DDS
Co-Investigator: E.Todd Scheyer, DDS, MS
2004 - 2006
A Phase II, Randomized, Double-Blind, Placebo-Controlled Study to Determine the Safety and Efficacy of Isolagen Injections for Treatment of Interdentally Papillary Insufficiency
Sponsor: Isolagen
Principal Investigator: Michael K. McGuire, DDS
Co-Investigator: E.Todd Scheyer, DDS, MS
2003 - 2004
A Blinded-Human clinical Trial to Evaluate the Clinical Utility of GEM 21S for the Treatment of General Bone Defects
Sponsor: Biomimetic Pharmaceuticals
Principal Investigator: Michael K. McGuire, DDS
Co-Investigator: E.Todd Scheyer, DDS, MS
2002 - 2003
A Randomized Double-Blind, Controlled, Parallel-Arm, Pivotal Human Clinical Trial to Evaluate the Safety and Effectiveness of B-TCP Plus for the Treatment of Periodontal Bone Defects
Sponsor: Biomimetic Pharmaceuticals
Principal Investigator: Michael K. McGuire, DDS
Co-Investigator: E.Todd Scheyer, DDS, MS
2000 - 2002
Free Autogenous Graft Pilot Study Utilizing Human Dermal Fibroblasts
Sponsor: Advanced Tissue Sciences
Principal Investigator: Michael K. McGuire, DDS
2000 - 2001
A Pilot Study of the Clinical applicability of the Minocycline Periodontal Therapeutics System When Used Adjunctively with Scaling and Root Planing for the Treatment of Non-Responding Periodontal Sites
Sponsor: OraPharma
Principal Investigator: Michael K. McGuire, DDS
1999 - 2001
The Evaluation of Emdogain ® in Treatment of Recession Type Defects
Sponsor: Biora
Principal Investigator: Michael K. McGuire, DDS
1994 - 1995
Host Factor Relationships in Periodontal Regenerative Therapy
Sponsor: Proctor & Gamble
Principal Investigator: Michael K. McGuire, DDS
1994
A Six Month Multicenter Evaluation of Adjunctive Tetracycline Fiber therapy used in Conjunction with Scaling and Root Planing in Maintenance Patients
Sponsor: Proctor & Gamble
Principal Investigator: Michael K. McGuire, DDS
1993 - 1994
Adjunctive use of Azithromycin in Treatment of Refractory Periodontitis
Sponsor: Proctor & Gamble
Principal Investigator: Michael K. McGuire, DDS
1990
Clinical and Microbial Patterns of Adults with Periodontitis
Sponsor: Michael K. McGuire, DDS
Principal Investigator: Michael K. McGuire, DDS
1989 - 1994
Open-Label Study to Evaluate Treatment Use of PTS (Periodontal Therapeutic System) (Tetracycline)
Sponsor: Proctor Gamble/Alza Corp
Principal Investigator: Michael K. McGuire, DDS
1989 - 1990
A Multi-Center Study to Evaluate Scaling & Root Planing With and Without PTS (Periodontal Therapeutic System) (Tetracycline) in Refractory Maintenance Patients
Sponsor: Alza Corp
Principal Investigator: Michael K. McGuire, DDS